Medicare may cover Xiidra (lifitegrast ophthalmic solution) if you have a plan with prescription drug coverage, such as a Part D plan or a Medicare Advantage (Part C) plan.

Xiidra is a brand-name drug that doctors may prescribe to treat the symptoms of dry eye disease.

Xiidra belongs to a group of drugs called a lymphocyte function-associated antigen-1 (LFA-1) antagonist. The drug is approved by the Food and Drug Administration (FDA) to treat the signs and symptoms of dry eye disease.

To receive coverage for Xiidra, you need to have a Medicare prescription drug plan.

If you have Original Medicare (parts A and B), you can enroll in a stand-alone Part D plan to cover your medications.

If you have a Medicare Advantage plan, you likely have prescription drug coverage as part of your plan. However, not all Medicare Advantage plans include drug benefits.

Private insurance companies offer Medicare drug plans, and their lists of covered drugs differ. Your plan will cover Xiidra if it’s included in the plan’s formulary. More than half of Medicare drug plans cover Xiidra.

Review your plan’s documentation or contact a representative to learn whether it covers Xiidra. If it does not, it may cover an alternative medication for dry eye disease.

The Centers for Medicare & Medicaid Services (CMS) offers a coverage finder tool to allow users to find plans in their area that include coverage for Xiidra.

The amount you pay for Xiidra will depend on a few factors. These include your location, your plan, and the drug’s tier.

Medicare prescription drug plans group covered drugs into cost tiers. Xiidra is typically a higher tier drug, with no generic version.

The amount you pay for Xiidra will also depend on what stage of coverage you are in.

In 2025, most Part D plans have three stages of coverage. Beneficiaries will have different out-of-pocket expenses depending on the stage:

  • Deductible stage: If your plan has a deductible, you’ll pay the full cost of the medication until you reach your deductible amount. In 2025, the maximum deductible amount for a Part D plan is $590.
  • Initial coverage stage: After meeting your deductible, you’ll pay a 25% coinsurance on the cost of covered medications until your out-of-pocket costs reach $2,000.
  • Catastrophic stage: Once you’ve spent $2,000 in a calendar year, you’ll pay no more for covered medications.

If you qualify for cost assistance through the Extra Help program, your costs will be lower.